Glutathione (GSH) is a prominant non-protein thiol with a concentration of 0.5 – 10 mM in mammalian cells, which serves as an intracellular reducing substance to protect the cells against oxidative stress. Glutathione Peroxidase (GPx) catalyzes the reduction of hydrogen peroxide (H2O2), using reduced GSH, and produces oxidized GSH dimer (GSSG). GSH also plays a critical role in many other biological processes, such as protein and DNA synthesis, and amino acids transport as well as protection of cells against oxidation. Considering the fact that the potent NFkB inducer TPA increases intracellular GSSG levels and GSSG/GSH ratios, it has been proposed that GSSG might play an important role in the NFkB activating signal cascade.
Catalog Number: ZXB-06-106
CAS Number: 70-18-8
Molecular Weight: 307.32
PubChem Chemical ID: 124886
Ordering: You can also order using info[at]zellx.de or FAX at +49(0)7336 4960027
Technical Support: Customer satisfaction is very important to us. Please call us at +49(0)7336 2279990 or send an email to technical[at]zellx.de with your technical questions. A member of our scientific staff will be glad to assist you.